Ph.D. Thuy Vy NGUYEN
Official tittle Doctor of Philosophy
Office Department of Genetics, Laboratory of Molecular biology
Current position Head of Department of Genetics
Email ntvy@hcmus.edu.vn
Member group
Education
2010-2013 PhD in Biology at Graduate school “Genes, Genomes, Cells”, University
Paris-Sud, France
2006-2009 MSc in Genetics, University of Science, VNU-HCMC
2001-2005 BSc in Biotechnology, University of Science, VNU-HCMC
Work experience
Lab of Molecular Biology, Department of Genetics, University of Science, HCMC, Vietnam.
2015-present PI of research project " Impact of Helicobacter pylori infection on
genetic stability incultured gastric epithelium cells”
Group “Fanconi anemia and DNA crosslinks repair”, UMR8200, Institute Gustave Roussy, France. Supervisor, Dr. Filippo Rosselli.
2010-2013 Thesis project “The roles of Fanconi anemia pathway in immunoglobulin
diversification”
03-08/2010 Research project “Functional characterization of interaction between
FANCD2 and the histone acetyltransferase Tip60 in FANC pathway”
Molecular Mechanisms of Dietary Components Group, Department of Science, Systems and Models, Roskilde University, Denmark. Supervisors, Associate Professor Ole Vang and Associate Professor Ho Huynh Thuy Duong
9/2006-01/2007 Master Thesis "Effects of resveratrol on human cancer cell adhesion"
Examined the influences of resveratrol on the adhesion of adherent DLD-1 and suspension HL-60 human promyelocytic leukemia cell lines and on expression and phosphorylation of FAK.
Lab of Molecular Biology, Department of Genetics, University of Science, HCMC, Vietnam. Supervisor, Associate Professor Ho Huynh Thuy Duong
2008-2009 Research project "Investigating antiproliferative activity of traditional remedies”
2007-2009 Collaborative project "Investigating antiproliferative activity of Vietnamese
medicinal plant extracts”
2006-2007 Research project "Establishment and standardization of screening protocols for
antiproliferative plant extracts”
01-08/2005 BSc Thesis "Determination of the optimal starvation-synchronizing time and
cell-cycle analysis of HEp-2 cells using flow cytometry technique"
Teaching
New problem in molecular biology - Master program
Labwork on moclecular biology - Undergraduate program
Biology of the cell - Master program
Practice course for Master program in Genetics - Master program
Major scientific interests
- Genetic stability and Oncogenesis: H. pylori infection and gastric cancer carcinogenesis
- Application of NGS in cancer, mendelian or complex diseases
- Bioactivity of natural products: Anticancer mechanism of traditional herbal remedies and natural compounds
Recent publication and conference presentations
International publication- Nguyen TV, Pawlikowska P, Firlej V, Rosselli F, Aoufouchi S. (2016). V(D)J recombination process and the Pre-B to immature B-cells transition are altered in Fanca−/− mice. Scientific Reports, 6: 36906.
- Le NT, Phan VH, Dang MAT, Nguyen TV. (2016). Estimation and Preparation of the Hypervariable Regions I/II Templates for Mitochondrial DNA Typing From Human Bones and Teeth Remains Using Singleplex Quantitative Polymerase Chain Reaction. The American journal of forensic medicine and pathology, 37 (3): 158-164.
- Bui QT, Bui TA, Nguyen TK, Nguyen TV, Trinh TDB, Nguyen DLH. (2016). A depsidone and six triterpenoids from the bark of Garcinia celebica. Tetrahedon Letters, 57(23):2524-2529.
- Nguyen TV, Riou L, Aoufouchi S, Rosselli F. (2014). Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells. J Exp Med, 211(6):1011-1018.
- Nguyen MN, Nguyen TV, Ho-Huynh TD. (2014). Combinative effects of Thanh hao miet giap thang (Sweet wormwood and tortoise shell decoction) ingredients on antioxidative activity in vitro. Afr J Tradit Complement Altern Med, 11(4):136-141.
- Ngo NT, Nguyen TV, Vo VH, Vang O, Duus F, Huynh-Ho TD, Pham DH, Nguyen DLH (2010). Cytotoxic Coumarins from the Bark of Mammea siamensis. Chem Pharm Bull, 58(11):1487-91.
- Nguyen TV, Nguyen-Thai HT, Tran NKV, Nguyen TH, Nguyen MN, Nguyen TB, Ho-Huynh TD (2010). In vitro antiproliferative activity of the traditional remedy Hoang lien giai doc thang and its components on human cervical cancer cell line HeLa. Journal of Biotechnology, 8(3A): 1-6 (in Vietnamese).
- Tat TT, Nguyen TV, Nguyen HN, Le CT, Truong XL, Ho-Huynh TD (2008). Investigation of the relationship between anti-proliferative activity and apoptosis induction of plant-derived agents on Hep-2 cancer cell line. Journal of Science and Technology Development, 11(7):5-10 (in Vietnamese).
- Franck T, Tat TT, Nguyen TV, Nguyen HN, Nguyen DLH, Nguyen KPP, Nguyen NH, Ho-Huynh TD (2008). Antiproliferative activity of Vietnamese medicinal plants on HeLa human cervical cancer cell line. Journal of Science and Technology Development, 11 (1):74-81 (in Vietnamese).
International conference
- Nguyen TV. H. pylori-induced alterations in gastric epithelial cells. The 10th Hallym – Vietnam National University Joint Symposium Program; 2016 December 6; Ho Chi Minh City, Vietnam.
- Pham Tran DT, Bui NN, Nguyen MT, Nguyen ST, Nguyen TV. VacA gene structure contributes to decreased expression of mismatch repair proteins induced by Helicobacter pylori in cultured gastric cancer cells. EHMSG XXIXth International Workshop on Helicobacter and Microbiota in Inflammation and Cancer; 2016 September 15-17; Magdeburg, Germany.
- Nguyen TV, Pawlikowska P, Firlej V, Aoufouchi S, Rosselli F. Fanca loss-of-function leads to altered diversification of immunoglobulin genes in differentiating B cells. 27th Annual Fanconi Anemia Research Fund Scientific Symposium; 2015 September 17-20; Toronto, Canada.
- Nguyen TV, Naim V, Aoufouchi S, Rosselli F. Reduced A/T transition in somatic hyperrmutation and altered class switch recombination junctions in FANCA-deficient mice. 10ème colloque des "3R"; 2013 May 21-24; la presqu'île de Giens, France.
- Naim V, Nguyen TV, Rosselli F. The FANC Pathway and Endonucleases in Fragile Site Stability. 24th Annual Fanconi Anemia Research Fund Scientific Symposium; 2012 September 27-30; Denver, USA.
- Nguyen TV, et al. Study of apoptosis induction effects of traditional remedies and quality control strategies. 59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research; 2011 September 4-9; Antalya, Turkey.
Honor & Award
2015-2017 TWAS Research Grants Programme in Basic Sciences
2016 Travel grant award, EMBO Practical Course “Targeted NGS in patients with
cancer, mendelian or complex diseases”, Poland
2012-2013 La Ligue Scholarship for 4th-year PhD student in France
2011 3rd Prize in "Creation in Science & Technology" competition, HCMC
2010-2012 Vietnamese government’s Scholarship for study PhD in France
2007-2008 Toshiba Scholarship for outstanding Master’s student
2007 1st Prize in "Creation in Science & Technology" competition, HCMC
2006-2007 DANIDA’s scholarship to study at Roskilde University for Master’s project
Scholarship of DAAD for further academic studies in Vietnam